Objectives: We will evaluate the influence of particle aggregation in the magnetic hyperthermia of colloidal gels in model tumors. NanoGe will provide hands-ont raining on the synthesis and surface functionalization of magnetic particles for their use in magnetic hyperthermia, the biological characterization of the particles and the evaluation of antitumoral properties based on hyperthermia including in vitro evaluation of antitumoral activity by MTT, Anexin / PI assay,migration assay by flow cytometry and confocal analysis. In collaboration with UGR, the PhD candidate will learn to operate a triaxial magnetic field generator to superimpose highly controlled fields on a model tumor. Sufficiently high frequencies will be applied to heat the particles. Tools will include rheometry in combination with confocal microscopy. Experimental results will be combined with computer simulations performed in collaboration with UU (de Graaf). Methods and protocols will be implemented in industrial systems within NanoGe.
Academicsecondment: The DC will be atUGR (16M/M20-M35) during which the PhD candidate will generate magnetic colloidal gels under a home- made unsteady triaxial magnetic field generator. UU (2M/M18 - M19): Learn to extend in-house simulation tools to account for dipolar interactions and magnetic fields. Compare experimental results on magnetic clusters formation with computer simulations.
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